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Beyond Discomfort: Recognizing & Treating Vascular Leg Pain

Each year, approximately 20% of adults aged 55 and older are affected by Peripheral Artery Disease (PAD), many of whom experience chronic leg pain as an early symptom (Nordanstig et al., 2023). Unfortunately, many people overlook these symptoms, unaware that vascular diseases like PAD or Chronic Venous Insufficiency (CVI) may be the underlying cause. Persistent leg pain, no matter its location—whether in the foot, calf, knee, or thigh—could indicate a vascular condition that requires medical attention.


Leg pain associated with vascular disease often presents in specific ways. It can range from a dull ache to intense, stabbing pain, and may occur at rest or during physical activity. Vascular leg pain may appear in one or both legs and is frequently accompanied by other symptoms like tingling, numbness, or coldness. Leg pain that occurs during physical exertion and ceases at rest, known as intermittent claudication, is a hallmark of PAD. As Golledge (2022) highlights, “PAD causes leg pain, impaired health-related quality of life, immobility, tissue loss, and a high risk of major adverse events.” Early diagnosis is essential to prevent progression to more severe conditions.

Risk Factors and Prevention

Some key risk factors increase the likelihood of developing PAD, CVI, and other vascular conditions. These include:

  • Diabetes: As Soyoye et al. (2021) note, “The prevalence of PAD is expected to increase owing to the rise in its major risk factors, including diabetes,” which heightens the risk of vascular complications like foot ulcers.
  • Smoking or tobacco use: Smoking constricts blood vessels and accelerates plaque buildup in the arteries, worsening vascular health.
  • Excess weight or obesity: Increased body weight puts added pressure on the vascular system, especially in the lower extremities.
  • High cholesterol or high blood pressure: Both conditions contribute to atherosclerosis, the buildup of plaque in arteries, which can block or reduce blood flow.
  • Family history of vascular or arterial disease: A family history of vascular disease may indicate a higher risk of PAD or CVI.

Preventive measures such as regular exercise, a heart-healthy diet, quitting smoking, and managing cholesterol and blood pressure levels can help reduce the likelihood of these conditions (Bevan & White Solaru, 2020). As emphasized in Bevan and White Solaru's study, “Medical management includes cholesterol reduction, antiplatelet therapy, anticoagulation, vasodilators, blood pressure control, exercise, and smoking cessation.”

What You Need to Know

If you experience chronic leg pain, it could be more than just discomfort; it may be an early indicator of vascular disease, highlighting the importance of early diagnosis and treatment.

PAD, also known as peripheral vascular disease, affects an estimated 18 million Americans, many of whom may be unaware of their condition (Nordanstig et al., 2023). PAD occurs when plaque buildup within the peripheral arteries restricts blood flow, often affecting the legs due to their higher demand for blood flow during movement. As Golledge (2022) states, “Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower limb arteries (peripheral artery disease (PAD)).” Common symptoms include:

  • Pain and cramping in the legs: Often the first sign, especially during activity (Bevan & White Solaru, 2020).
  • Non-healing sores on the legs or feet: Restricted blood flow hampers the body’s ability to heal.
  • Weak or absent pulse in feet or legs: Diminished blood circulation may reduce or eliminate detectable pulses in the extremities.
  • Changes in skin texture or color: Shiny skin, hair loss, or unusual pallor can indicate vascular issues (Golledge, 2022).

If left untreated, PAD can progress to critical limb ischemia (CLI), leading to gangrene or even limb amputation. Early recognition and management, including lifestyle changes and, in some cases, revascularization (surgical restoration of blood flow), are crucial. The multidisciplinary approach recommended by Hinchliffe et al. (2020) suggests that “After a revascularization procedure in a patient with a diabetic foot ulcer, the patient should be treated by a multidisciplinary team as part of a comprehensive care plan.”


CVI, another common vascular issue, occurs when veins in the legs struggle to return blood to the heart. This condition can lead to pooling blood in the legs, which causes pain, swelling, and a sensation of heaviness. CVI affects around 40% of the U.S. population, though many remain unaware of their condition. This condition is often more prevalent in women with multiple pregnancies and individuals aged 50 and older. As Hinchliffe et al. (2020) note, “Patients with diabetes and PAD are at an elevated risk of other cardiovascular diseases, necessitating additional preventive strategies for cardiovascular health management.”

Symptoms of CVI often overlap with those of PAD and include:

  • Pain and heaviness in the legs: Especially after long periods of standing.
  • Swelling and discoloration: Pooling blood creates pressure on vein walls, leading to skin changes.
  • Reduced mobility: The discomfort can restrict movement, leading to a sedentary lifestyle, which exacerbates vascular problems.


Managing PAD, CVI, and other vascular conditions begins with lifestyle modifications. Regular physical activity, a balanced diet, and smoking cessation can significantly impact vascular health (Soyoye et al., 2021). “Exercise, statins, antiplatelet therapy, and blood pressure control are essential in managing PAD in DM patients to improve outcomes and prevent complications” (Soyoye et al., 2021). Consulting a vascular specialist is advisable for anyone with persistent leg pain, especially if it’s accompanied by other symptoms like leg discoloration or non-healing sores.


Both PAD and CVI are progressive diseases with potentially serious complications, including heart attack, stroke, and limb loss. Golledge (2022) emphasizes that “PAD causes leg pain, impaired health-related quality of life, immobility, tissue loss, and a high risk of major adverse events.” With early diagnosis and proper management, patients can avoid the most severe outcomes.


Guaynabo Vascular Specialists Clinical Services

At Guaynabo Vascular Specialists, comprehensive PAD and CVI care is provided Monday through Friday, from 6:30 AM to 1:00 PM. Immediate medical evaluation is advised if experiencing acute symptoms such as leg pain, non-healing sores, or discoloration. Advanced therapies are available for both PAD and CVI, aiming to restore function and prevent serious complications, including limb loss and cardiovascular events. If experiencing chronic leg pain or other PAD symptoms, consult our vascular specialist in Guaynabo to determine the appropriate diagnosis and treatment pathway.

References

Bevan, G. H., & White Solaru, K. T. (2020). Evidence-based medical management of peripheral artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(3), 541-553. https://doi.org/10.1161/ATVBAHA.119.312142


Golledge, J. (2022). Update on the pathophysiology and medical treatment of peripheral artery disease. Nature Reviews Cardiology, 19(7), 456-474. https://doi.org/10.1038/s41569-021-00663-9


Hinchliffe, R. J., Forsythe, R. O., Apelqvist, J., Boyko, E. J., Fitridge, R., Hong, J. P., Katsanos, K., Mills, J. L., Nikol, S., Reekers, J., & Venermo, M. (2020). Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update). Diabetes/Metabolism Research and Reviews, 36(S1), e3276. https://doi.org/10.1002/dmrr.3276


Nordanstig, J., Behrendt, C. A., Bradbury, A. W., de Borst, G. J., Fowkes, F. G. R., Golledge, J., Gottsater, A., Hinchliffe, R. J., Nikol, S., & Norgren, L. (2023). Peripheral arterial disease (PAD): A challenging manifestation of atherosclerosis. Preventive Medicine, 171, 107489. https://doi.org/10.1016/j.ypmed.2023.107489


Signorelli, S. S., Marino, E., Scuto, S., & Di Raimondo, D. (2020). Pathophysiology of peripheral arterial disease (PAD): A review on oxidative disorders. International Journal of Molecular Sciences, 21(12), 4393. https://doi.org/10.3390/ijms21124393


Soyoye, D. O., Abiodun, O. O., Ikem, R. T., Kolawole, B. A., & Akintomide, A. O. (2021). Diabetes and peripheral artery disease: A review. World Journal of Diabetes, 12(6), 827-838. https://doi.org/10.4239/wjd.v12.i6.827

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